“Great to see ur staff are doing their job properly”

Facing obstacles, yet doing one's job properly.

Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?

Langerhans cell histiocytosis (LCH) is the unifying designation for a rare proliferative disorder that occurs predominantly in childhood and involves the main antigen-presenting cell of the epidermis. LCH can present in a multitude of ways, from a self-limited rash that resolves spontaneously to a systemic multi-organ disease with a 20% mortality rate. Because some forms behave in a relatively ...

Back to basics: explaining sample size in outcome trials, are statisticians doing a thorough job?

Time to event outcome trials in clinical research are typically large, expensive and high-profile affairs. Such trials are commonplace in oncology and cardiovascular therapeutic areas but are also seen in other areas such as respiratory in indications like chronic obstructive pulmonary disease. Their progress is closely monitored and results are often eagerly awaited. Once available, the top li...

Doing staff development: Practices, dilemmas and technologies

Online learning technologies now pervade higher education institutions, and the convergence of teaching and learning onto technological systems has created new work practices and a demand for staff development. Educational developers are located at a nexus between the institutional and pragmatic imperatives, from which tensions and incongruencies emerge and need to be resolved in daily practice...

Are We Examining Our Patients Properly and Can We Do a Better Job?

in a patient with mixed connective tissue disease: An unusual complication. Lupus. 2010;19:1005--6. 12. Falchi L, Capello D, Palumbo B, Rauco A, Emili R, Cianciulli M, et al. A case of nodular sclerosis Hodgkin’s lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman’s disease: Successful response to rituximab and radiotherapy. Eur J Haematol. 2007;79:4...